In the lab, I use Caenorhabditis elegans, as a model to study the effects of chemical exposures on the nervous system, and the interaction of this relationship with the aging process.
References:
Cole, T. B. et al. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 374, 1–9 (2016).
*Bradner JM, Kalia V, Lau FK, et al. Genetic or toxicant induced disruption of vesicular monoamine storage and global metabolic profiling in Caenorhabditis elegans. bioRxiv. Published online October 2, 2020:2020.10.02.324095. doi:10.1101/2020.10.02.324095*
*Mor DE, Sohrabi S, Kaletsky R, et al. Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria. PNAS. Published online October 6, 2020. doi:10.1073/pnas.2009838117*